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How to Choose a Softgel Encapsulation Machine

A practical guide to capsule shells and shapes, RG capacity from lab to mega-scale, servo dosing accuracy, GMP materials, and matching RG-100/300/500/8800 models to your output.

CEcGMPISO 9001:2015FDA 21 CFR Part 11

1. Start With Your Product Form

Softgel (soft capsule) encapsulation is ideal for oils, suspensions, and pastes - fish oil, vitamins, coenzyme Q10, and other oxygen-sensitive actives. Confirm your fill matrix first, because it drives pump type and drying parameters rather than machine size.

2. Capsule Shell & Shape

GelatinHPMCPullulanOvalOblongRoundCylindrical

Yoho Industrial RG lines support gelatin, HPMC, and pullulan shells in sizes 5-24 mm (custom 3-30 mm). Vegetarian HPMC and pullulan enable halal and kosher clean-label lines. Die rolls swap in 15-30 minutes across multiple shapes.

3. Capacity: Lab to Mega-Scale

RG-100
5-10k/hr

Lab, min batch 500

RG-300
20-30k/hr

Pilot, up to 40k opt

RG-500
40-60k/hr

Industrial 24/7

RG-8800
228k/hr

Mega-scale multi-die

4. Filling Accuracy & Dosing

A servo-controlled gear pump delivers +/-2% accuracy, with an optional precision flow meter reaching +/-1% for high-value actives. In-process weight control and automatic reject protect batch consistency on every run.

5. Changeover & Batch Size

Tool-free die-roll swaps take 15-30 minutes across multiple capsule shapes, and minimum batch sizes start at 500 capsules on the RG-100 for formulation screening and bioavailability studies.

6. GMP Materials & Construction

All product-contact surfaces are 316L stainless steel with Ra <=0.4 um, CIP-compatible, with full DQ/IQ/OQ/PQ documentation. Certifications: CE, cGMP, ISO 9001:2015.

7. Drying & In-Line Quality

Encapsulated capsules dry at 25C and 30% RH over 4-8 hours. The RG-8800 adds integrated vision and weight-check stations with automatic reject of off-spec capsules, plus MES-ready data logging for mega-scale plants.

8. Match Yoho RG Models

Start on the RG-100 for R&D, scale to RG-300 for pilot, RG-500 for commercial 24/7, and RG-8800 for contract-manufacturing mega-volume with integrated inspection.

ModelTypeCapacityCapsule sizeBest for
RG-100Lab rotary die5-10k caps/hr5-24 mmR&D, screening
RG-300Pilot20-30k (40k opt)5-24 mmPilot, mid volume
RG-500Industrial40-60k caps/hr5-24 mmCommercial 24/7
RG-8800Multi-die228k caps/hr5-24 mmMega-scale, contract
Yoho Industrial RG Series softgel encapsulation machine

Frequently Asked Questions

What is the RG series used for?

The RG series performs softgel (soft capsule) encapsulation of oils, suspensions, and pastes - fish oil, vitamins, CoQ10, and other actives - using rotary die technology. It is the right choice when the fill is liquid or semi-liquid rather than powder. RG lines cover lab screening through mega-scale contract manufacturing on one platform.

What capacity do I need?

RG-100 runs 5-10k caps/hr for labs with a 500-capsule minimum batch, RG-300 reaches 20-30k/hr (40k optional) for pilot, RG-500 delivers 40-60k/hr for commercial 24/7, and RG-8800 hits 228k/hr for contract mega-volume. A single shift at 30k/hr yields about 240,000 capsules, so size for your peak month.

What capsule sizes and shapes are possible?

RG lines handle sizes 5-24 mm, custom 3-30 mm, in oval, oblong, round, and cylindrical shapes. Shells can be gelatin, HPMC, or pullulan, with die-roll swaps in 15-30 minutes across formats. This flexibility lets one line serve multiple SKUs and clean-label vegetarian products without new tooling.

What is the dosing accuracy?

A servo-controlled gear pump gives +/-2% accuracy, with an optional precision flow meter reaching +/-1% for high-value actives. In-process weight control and automatic reject maintain batch consistency on every run. Minimum batch sizes start at just 500 capsules on the RG-100, ideal for formulation screening.

Is the equipment GMP certified?

Yes. Product-contact parts are 316L stainless steel with Ra <=0.4 um, CIP-compatible, and every machine ships with DQ/IQ/OQ/PQ protocols. RG lines are CE marked, cGMP, and ISO 9001:2015 certified. The RG-8800 additionally provides MES-ready data logging for large-scale audit-driven plants.

How fast is die changeover?

Tool-free die-roll swaps take 15-30 minutes across multiple capsule shapes and sizes. The RG-100 supports minimum batches of 500 capsules, ideal for formulation screening and bioavailability studies. Quick changeover lets contract manufacturers switch client formulations within a single shift without losing production days.

Do you support vegetarian and clean-label shells?

Yes. Standard HPMC and pullulan shell support enables halal and kosher clean-label supplement lines in addition to conventional gelatin, all on the same RG platform. Vegetarian shells are processed with the same servo dosing and sealing, so clean-label SKUs do not require a separate machine.

What about drying and inspection?

Capsules dry at 25C and 30% RH over 4-8 hours in a controlled tumble zone. The RG-8800 adds integrated in-line vision and weight-check stations with automatic reject of off-spec capsules, plus MES-ready data logging. Nitrogen flushing and leak-proof sealing protect oxygen-sensitive omega-3 and CoQ10 actives.

Ready to Specify Your Equipment?

Send your product type, target output, and specs for a tailored quote.